Possibly. If a voltage greater than 16 Vdc is applied to the wiring panel, it could damage the input and result in inaccurate measurements.
Additionally, in some cases the sensors can be damaged if they are wired to the wrong channels. If a sensor, wired into an analog input channel, has an output of more than 5 Vdc, measurements on adjacent analog input channels may be upset. For example, the maximum full-scale range on the CR5000 is ± 5Vdc.